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Balaram Mukhopadhyay,
PhD

Synthetic Carbohydrate Chemistry

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Complex Carbohydrates are involved in numerous biological events and thus constitute an important class of biomolecules. The prime focus of our group is the Chemical Synthesis of Biologically Relevant Oligosaccharides that can be utilized for designing glycoconjugates and vaccine designing. In the process we attend the need of developing novel techniques for protecting group manipulations on carbohydrate structures and efficient stereoselective glycosylation. In addition, we are looking at the possibilities of developing Bio-markers for the detection of proteins/lectins through the specific interactions of saccharides decorated on metal complexes and nanoparticles. Recently our lab is significantly engaged in developing Low Molecular Weight Organogels/Hydrogels by the supramolecular assembly of carbohydrate molecules.

Research Focus Areas

Unicellular bacteria are continuously intriguing us with newer complex oligosaccharides that are posing challenges for the synthetic carbohydrate chemists for their chemical synthesis. The potential of O-antigen repeating units towards the development of synthetic/semi-synthetic vaccines continues to attract synthetic chemists to formulate accurate and scalable synthetic protocols to get these complex oligosaccharides in the purest possible form.

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Research Publications

Rituparna Das and Balaram Mukhopadhyay, "Chemical O-glycosylations: an overview" ChemistryOPEN 20165, 401-433.

Sanajit Maiti and Balaram Mukhopadhyay, "Total synthesis of the D-acofriose-containing trisaccharide repeating unit of the O-antigen from Azospirillum brasilense JM6B2" Org. Biomol. Chem. 2025, 23, 5847-5856.

Contact

Sweet Lab, Department of Chemical Sciences
IISER Kolkata

Mohanpur, Nadia 741246
West Bengal, INDIA

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